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TNF-α Mediate Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation
The Nlrp3 inflammasome is critical for the activation of caspase-1 in response to danger signals and particulate matter. However, its role in sterile inflammation remains unclear because pre-stimulation of phagocytic cells with microbial molecules is required for caspase-1 activation. We show here t...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2754237/ https://ncbi.nlm.nih.gov/pubmed/19542372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900173 |
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