Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

Disease recurrence causes significant mortality in B-progenitor acute lymphoblastic leukemia (B-ALL). Genomic analysis of matched diagnosis and relapse samples show relapse often arising from minor diagnosis subclones. However, why therapy eradicates some subclones while others survive and progress...

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I publikationen:Cancer Discov
Huvudupphovsmän: Dobson, Stephanie M., García-Prat, Laura, Vanner, Robert J., Wintersinger, Jeffrey, Waanders, Esmé, Gu, Zhaohui, McLeod, Jessica, Gan, Olga I., Grandal, Ildiko, Payne-Turner, Debbie, Edmonson, Michael N., Ma, Xiaotu, Fan, Yiping, Voisin, Veronique, Chan-Seng-Yue, Michelle, Xie, Stephanie Z., Hosseini, Mohsen, Abelson, Sagi, Gupta, Pankaj, Rusch, Michael, Shao, Ying, Olsen, Scott R., Neale, Geoffrey, Chan, Steven M., Bader, Gary, Easton, John, Guidos, Cynthia J., Danska, Jayne S., Zhang, Jinghui, Minden, Mark D., Morris, Quaid, Mullighan, Charles G., Dick, John E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7122013/
https://ncbi.nlm.nih.gov/pubmed/32086311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-1059
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