Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors

Defects in the nonhomologous end-joining (NHEJ) pathway of double-stranded DNA break repair severely impair V(D)J joining and selectively predispose mice to the development of lymphoid neoplasia. This connection was first noted in mice with the severe combined immune deficient (SCID) mutation in the...

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Autores principales: Williams, Christine J., Grandal, Ildiko, Vesprini, Danny J., Wojtyra, Urszula, Danska, Jayne S., Guidos, Cynthia J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC86582/
https://ncbi.nlm.nih.gov/pubmed/11134329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.2.400-413.2001
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