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Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

In addition to creating the DNA double strand breaks that initiate V(D)J recombination, the RAG proteins are thought to play a critical role in the joining phase of the reaction. One such role, suggested by in vitro studies, might be to ensure the structural integrity of postcleavage complexes, but...

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Bibliografiska uppgifter
Huvudupphovsmän: Tsai, Chia-Lun, Drejer, Anna H., Schatz, David G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2002
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC186421/
https://ncbi.nlm.nih.gov/pubmed/12154124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.984502
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