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Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

In addition to creating the DNA double strand breaks that initiate V(D)J recombination, the RAG proteins are thought to play a critical role in the joining phase of the reaction. One such role, suggested by in vitro studies, might be to ensure the structural integrity of postcleavage complexes, but...

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書目詳細資料
Main Authors: Tsai, Chia-Lun, Drejer, Anna H., Schatz, David G.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2002
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC186421/
https://ncbi.nlm.nih.gov/pubmed/12154124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.984502
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