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Mobilization of RAG-Generated Signal Ends by Transposition and Insertion In Vivo

In addition to their essential roles in V(D)J recombination, the RAG proteins have been found to catalyze transposition in vitro, but it has been difficult to demonstrate transposition by the RAG proteins in vivo in vertebrate cells. As genomic instability and chromosomal translocations are common o...

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Detalhes bibliográficos
Main Authors: Chatterji, Monalisa, Tsai, Chia-Lun, Schatz, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1367191/
https://ncbi.nlm.nih.gov/pubmed/16449665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.4.1558-1568.2006
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