Llwytho...
Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase
Jawed vertebrate adaptive immunity relies on the RAG1/RAG2 (RAG) recombinase, a domesticated transposase, for assembly of antigen receptor genes. Using an integration‐activated form of RAG1 with methionine at residue 848 and cryo‐electron microscopy, we determined structures that capture RAG engaged...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | EMBO J |
|---|---|
| Prif Awduron: | , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
John Wiley and Sons Inc.
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7604617/ https://ncbi.nlm.nih.gov/pubmed/32945578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105857 |
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