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Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase
Jawed vertebrate adaptive immunity relies on the RAG1/RAG2 (RAG) recombinase, a domesticated transposase, for assembly of antigen receptor genes. Using an integration‐activated form of RAG1 with methionine at residue 848 and cryo‐electron microscopy, we determined structures that capture RAG engaged...
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| Pubblicato in: | EMBO J |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7604617/ https://ncbi.nlm.nih.gov/pubmed/32945578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105857 |
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