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Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase

Jawed vertebrate adaptive immunity relies on the RAG1/RAG2 (RAG) recombinase, a domesticated transposase, for assembly of antigen receptor genes. Using an integration‐activated form of RAG1 with methionine at residue 848 and cryo‐electron microscopy, we determined structures that capture RAG engaged...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Zhang, Yuhang, Corbett, Elizabeth, Wu, Shenping, Schatz, David G
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604617/
https://ncbi.nlm.nih.gov/pubmed/32945578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105857
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