Zebrafish MITF-low melanoma subtype models reveal transcriptional subclusters and MITF-independent residual disease

The MITF-low melanoma transcriptional signature is predictive of poor outcomes for patients but little is known about its biological significance and animal models are lacking. Here, we used zebrafish genetic models with low activity of Mitfa (MITF-low) and established that the MITF-low state is cau...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Travnickova, Jana, Wojciechowska, Sonia, Khamseh, Ava, Gautier, Philippe, Brown, Daniel V., Lefevre, Thomas, Brombin, Alessandro, Ewing, Ailith, Capper, Amy, Spitzer, Michaela, Dilshat, Ramile, Semple, Colin A., Mathers, Marie E., Lister, James A., Steingrimsson, Eiríkur, Voet, Thierry, Ponting, Chris P., Patton, E. Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116150/
https://ncbi.nlm.nih.gov/pubmed/31582381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-0037
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