A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

The microphthalmia-associated transcription factor (MITF) is the “master melanocyte transcription factor” with a complex role in melanoma. MITF protein levels vary between and within clinical specimens, and amplifications and gain- and loss-of-function mutations have been identified in melanoma. How...

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Detalhes bibliográficos
Main Authors: Lister, James A, Capper, Amy, Zeng, Zhiqiang, Mathers, Marie E, Richardson, Jennifer, Paranthaman, Karthika, Jackson, Ian J, Patton, E Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898314/
https://ncbi.nlm.nih.gov/pubmed/23831555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.293
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