Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41

Entry of human immunodeficiency virus type 1 (HIV-1) into target cells is mediated by its envelope protein gp41 through membrane fusion. Interaction of two extra-virion heptad repeats (HRs) in the gp41 plays a pivotal role in the fusion, and its inhibitor, enfuvirtide (T-20), blocks HIV-1 entry. To...

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Publicado no:Antiviral Res
Main Authors: Nishikawa, Hiroki, Kodama, Eiichi, Sakakibara, Ayako, Fukudome, Ayako, Izumi, Kazuki, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114109/
https://ncbi.nlm.nih.gov/pubmed/18584890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.05.006
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