Potent anti-HIV-1 activity of N-HR-derived peptides including a deep pocket-forming region without antagonistic effect on T-20

BACKGROUND: Enfuvirtide (T20), a C-terminal heptad repeat (C-HR)-derived peptide of the human immunodeficiency virus type 1 (HIV-1) glycoprotein, gp41, effectively suppresses HIV-1 replication through a putative mechanism that involves its acting as a decoy and binding to the N-terminal heptad repea...

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Publicado en:Antivir Chem Chemother
Main Authors: Izumi, Kazuki, Watanabe, Kentaro, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao, Sarafianos, Stefan G., Kodama, Eiichi N.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4584145/
https://ncbi.nlm.nih.gov/pubmed/21860071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP1836
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