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Potent CXCR4 Antagonists Containing Amidine Type Peptide Bond Isosteres
[Image: see text] A series of FC131 [cyclo(-d-Tyr-Arg-Arg-Nal-Gly-)] analogues containing amidine type peptide bond isosteres were synthesized as selective CXC chemokine receptor type 4 (CXCR4) antagonists. An isosteric amidine substructure was constructed by a macrocyclization process using nitrile...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018133/ https://ncbi.nlm.nih.gov/pubmed/24900333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200047e |
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