The Peptidomimetic CXCR4 Antagonist TC14012 Recruits β-Arrestin to CXCR7: ROLES OF RECEPTOR DOMAINS

CXCR7 is an atypical chemokine receptor that signals through β-arrestin in response to agonists without detectable activation of heterotrimeric G-proteins. Its cognate chemokine ligand CXCL12 also binds CXCR4, a chemokine receptor of considerable clinical interest. Here we report that TC14012, a pep...

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Bibliografiske detaljer
Main Authors: Gravel, Stéphanie, Malouf, Camille, Boulais, Philip E., Berchiche, Yamina A., Oishi, Shinya, Fujii, Nobutaka, Leduc, Richard, Sinnett, Daniel, Heveker, Nikolaus
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992227/
https://ncbi.nlm.nih.gov/pubmed/20956518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.147470
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