Potent CXCR4 Antagonists Containing Amidine Type Peptide Bond Isosteres

[Image: see text] A series of FC131 [cyclo(-d-Tyr-Arg-Arg-Nal-Gly-)] analogues containing amidine type peptide bond isosteres were synthesized as selective CXC chemokine receptor type 4 (CXCR4) antagonists. An isosteric amidine substructure was constructed by a macrocyclization process using nitrile...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Inokuchi, Eriko, Oishi, Shinya, Kubo, Tatsuhiko, Ohno, Hiroaki, Shimura, Kazuya, Matsuoka, Masao, Fujii, Nobutaka
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2011
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018133/
https://ncbi.nlm.nih.gov/pubmed/24900333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200047e
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