SC29EK, a Peptide Fusion Inhibitor with Enhanced α-Helicity, Inhibits Replication of Human Immunodeficiency Virus Type 1 Mutants Resistant to Enfuvirtide

Peptides derived from the α-helical domains of human immunodeficiency virus (HIV) type 1 (HIV-1) gp41 inhibit HIV-1 fusion to the cell membrane. Enfuvirtide (T-20) is a peptide-based drug that targets the step of HIV fusion, and as such, it effectively suppresses the replication of HIV-1 strains tha...

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Bibliographic Details
Main Authors: Naito, Takeshi, Izumi, Kazuki, Kodama, Eiichi, Sakagami, Yasuko, Kajiwara, Keiko, Nishikawa, Hiroki, Watanabe, Kentaro, Sarafianos, Stefan G., Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650564/
https://ncbi.nlm.nih.gov/pubmed/19114674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01211-08
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