Design of Peptide-based Inhibitors for Human Immunodeficiency Virus Type 1 Strains Resistant to T-20

Enfuvirtide (T-20) is a fusion inhibitor that suppresses replication of human immunodeficiency virus (HIV) variants with multi-drug resistance to reverse transcriptase and protease inhibitors. It is a peptide derived from the C-terminal heptad repeat (C-HR) of HIV-1 gp41, and it prevents interaction...

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Main Authors: Izumi, Kazuki, Kodama, Eiichi, Shimura, Kazuya, Sakagami, Yasuko, Watanabe, Kentaro, Ito, Saori, Watabe, Tsuyoshi, Terakawa, Yukihiro, Nishikawa, Hiroki, Sarafianos, Stefan G., Kitaura, Kazuo, Oishi, Shinya, Fujii, Nobutaka, Matsuoka, Masao
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2009
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643509/
https://ncbi.nlm.nih.gov/pubmed/19073606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807169200
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