The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most frequent cause of recessive Parkinson's disease (PD). Parkin translocates from the cytosol to depolarized mitochondria, ubiquitinates outer mitochondrial membrane proteins and induces selective a...

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Detaylı Bibliyografya
Yayımlandı:Hum Mol Genet
Asıl Yazarlar: Cornelissen, Tom, Haddad, Dominik, Wauters, Fieke, Van Humbeeck, Cindy, Mandemakers, Wim, Koentjoro, Brianada, Sue, Carolyn, Gevaert, Kris, De Strooper, Bart, Verstreken, Patrik, Vandenberghe, Wim
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108632/
https://ncbi.nlm.nih.gov/pubmed/24852371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu244
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