The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy

Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are the most frequent cause of recessive Parkinson's disease (PD). Parkin translocates from the cytosol to depolarized mitochondria, ubiquitinates outer mitochondrial membrane proteins and induces selective a...

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Publicat a:Hum Mol Genet
Autors principals: Cornelissen, Tom, Haddad, Dominik, Wauters, Fieke, Van Humbeeck, Cindy, Mandemakers, Wim, Koentjoro, Brianada, Sue, Carolyn, Gevaert, Kris, De Strooper, Bart, Verstreken, Patrik, Vandenberghe, Wim
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7108632/
https://ncbi.nlm.nih.gov/pubmed/24852371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu244
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