LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

Parkinson disease (PD) is a disabling, incurable disorder with increasing prevalence in the western world. In rare cases PD is caused by mutations in the genes for PINK1 (PTEN induced kinase 1) or PRKN (parkin RBR E3 ubiquitin protein ligase), which impair the selective autophagic elimination of dam...

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Vydáno v:Autophagy
Hlavní autoři: Wauters, Fieke, Cornelissen, Tom, Imberechts, Dorien, Martin, Shaun, Koentjoro, Brianada, Sue, Carolyn, Vangheluwe, Peter, Vandenberghe, Wim
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984591/
https://ncbi.nlm.nih.gov/pubmed/30945962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1603548
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