LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

Parkinson disease (PD) is a disabling, incurable disorder with increasing prevalence in the western world. In rare cases PD is caused by mutations in the genes for PINK1 (PTEN induced kinase 1) or PRKN (parkin RBR E3 ubiquitin protein ligase), which impair the selective autophagic elimination of dam...

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Bibliografski detalji
Izdano u:Autophagy
Glavni autori: Wauters, Fieke, Cornelissen, Tom, Imberechts, Dorien, Martin, Shaun, Koentjoro, Brianada, Sue, Carolyn, Vangheluwe, Peter, Vandenberghe, Wim
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984591/
https://ncbi.nlm.nih.gov/pubmed/30945962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1603548
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