LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10

Parkinson disease (PD) is a disabling, incurable disorder with increasing prevalence in the western world. In rare cases PD is caused by mutations in the genes for PINK1 (PTEN induced kinase 1) or PRKN (parkin RBR E3 ubiquitin protein ligase), which impair the selective autophagic elimination of dam...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Wauters, Fieke, Cornelissen, Tom, Imberechts, Dorien, Martin, Shaun, Koentjoro, Brianada, Sue, Carolyn, Vangheluwe, Peter, Vandenberghe, Wim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6984591/
https://ncbi.nlm.nih.gov/pubmed/30945962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1603548
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