Neuronal CXCL10/CXCR3 Axis Mediates the Induction of Cerebral Hyperexcitability by Peripheral Viral Challenge

Peripheral infections can potently exacerbate neuropathological conditions, though the underlying mechanisms are poorly understood. We have previously demonstrated that intraperitoneal (i.p.) injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC) induces a robust generation of CXCL10 ch...

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Udgivet i:Front Neurosci
Main Authors: Petrisko, Tiffany J., Bloemer, Jenna, Pinky, Priyanka D., Srinivas, Sriraja, Heslin, Ryan T., Du, Yifeng, Setti, Sharay E., Hong, Hao, Suppiramaniam, Vishnu, Konat, Gregory W., Reed, Miranda N.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105801/
https://ncbi.nlm.nih.gov/pubmed/32265633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2020.00220
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