Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA

Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. In Eukarya and Archaea, the processivity of replicative DNAPs is greatly enhanced by its binding to the proliferative cell nuclear antigen (PCNA) that encircles the DNA. We determined...

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Pubblicato in:Nat Commun
Autori principali: Madru, Clément, Henneke, Ghislaine, Raia, Pierre, Hugonneau-Beaufet, Inès, Pehau-Arnaudet, Gérard, England, Patrick, Lindahl, Erik, Delarue, Marc, Carroni, Marta, Sauguet, Ludovic
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101311/
https://ncbi.nlm.nih.gov/pubmed/32221299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15392-9
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