Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases

PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has...

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Détails bibliographiques
Publié dans:PLoS Biol
Auteurs principaux: Raia, Pierre, Carroni, Marta, Henry, Etienne, Pehau-Arnaudet, Gérard, Brûlé, Sébastien, Béguin, Pierre, Henneke, Ghislaine, Lindahl, Erik, Delarue, Marc, Sauguet, Ludovic
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6355029/
https://ncbi.nlm.nih.gov/pubmed/30657780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000122
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