Structural basis of human PCNA sliding on DNA

Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show that the human clamp PCNA recognizes DNA through a double pat...

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Udgivet i:Nat Commun
Main Authors: De March, Matteo, Merino, Nekane, Barrera-Vilarmau, Susana, Crehuet, Ramon, Onesti, Silvia, Blanco, Francisco J., De Biasio, Alfredo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234079/
https://ncbi.nlm.nih.gov/pubmed/28071730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13935
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