Structural basis of human PCNA sliding on DNA

Sliding clamps encircle DNA and tether polymerases and other factors to the genomic template. However, the molecular mechanism of clamp sliding on DNA is unknown. Using crystallography, NMR and molecular dynamics simulations, here we show that the human clamp PCNA recognizes DNA through a double pat...

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發表在:Nat Commun
Main Authors: De March, Matteo, Merino, Nekane, Barrera-Vilarmau, Susana, Crehuet, Ramon, Onesti, Silvia, Blanco, Francisco J., De Biasio, Alfredo
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5234079/
https://ncbi.nlm.nih.gov/pubmed/28071730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13935
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