p15(PAF) binding to PCNA modulates the DNA sliding surface

p15(PAF) is an oncogenic intrinsically disordered protein that regulates DNA replication and lesion bypass by interacting with the human sliding clamp PCNA. In the absence of DNA, p15(PAF) traverses the PCNA ring via an extended PIP-box that contacts the sliding surface. Here, we probed the atomic-s...

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Gardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: De March, Matteo, Barrera-Vilarmau, Susana, Crespan, Emmanuele, Mentegari, Elisa, Merino, Nekane, Gonzalez-Magaña, Amaia, Romano-Moreno, Miguel, Maga, Giovanni, Crehuet, Ramon, Onesti, Silvia, Blanco, Francisco J, De Biasio, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6182140/
https://ncbi.nlm.nih.gov/pubmed/30102405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky723
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