Differential decay of intact and defective proviral DNA in HIV-1–infected individuals on suppressive antiretroviral therapy

BACKGROUND: The relative stabilities of the intact and defective HIV genomes over time during effective antiretroviral therapy (ART) have not been fully characterized. METHODS: We used the intact proviral DNA assay (IPDA) to estimate the rate of change of intact and defective proviruses in HIV-infec...

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Pubblicato in:JCI Insight
Autori principali: Peluso, Michael J., Bacchetti, Peter, Ritter, Kristen D., Beg, Subul, Lai, Jun, Martin, Jeffrey N., Hunt, Peter W., Henrich, Timothy J., Siliciano, Janet D., Siliciano, Robert F., Laird, Gregory M., Deeks, Steven G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
Soggetti:
Clinical Medicine
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101154/
https://ncbi.nlm.nih.gov/pubmed/32045386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132997
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