Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA

A scalable approach for quantifying intact HIV-1 proviruses is critical for basic research and clinical trials directed at HIV-1 cure. The intact proviral DNA assay (IPDA) is a novel approach to characterizing the HIV-1 reservoir, focusing on the genetic integrity of individual proviruses independen...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Simonetti, Francesco R., White, Jennifer A., Tumiotto, Camille, Ritter, Kristen D., Cai, Mian, Gandhi, Rajesh T., Deeks, Steven G., Howell, Bonnie J., Montaner, Luis J., Blankson, Joel N., Martin, Albine, Laird, Gregory M., Siliciano, Robert F., Mellors, John W., Siliciano, Janet D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414172/
https://ncbi.nlm.nih.gov/pubmed/32690683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006816117
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