Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA

A scalable approach for quantifying intact HIV-1 proviruses is critical for basic research and clinical trials directed at HIV-1 cure. The intact proviral DNA assay (IPDA) is a novel approach to characterizing the HIV-1 reservoir, focusing on the genetic integrity of individual proviruses independen...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Simonetti, Francesco R., White, Jennifer A., Tumiotto, Camille, Ritter, Kristen D., Cai, Mian, Gandhi, Rajesh T., Deeks, Steven G., Howell, Bonnie J., Montaner, Luis J., Blankson, Joel N., Martin, Albine, Laird, Gregory M., Siliciano, Robert F., Mellors, John W., Siliciano, Janet D.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414172/
https://ncbi.nlm.nih.gov/pubmed/32690683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006816117
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