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Function-based high-throughput screening for antibody antagonists and agonists against G protein-coupled receptors
Hybridoma and phage display are two powerful technologies for isolating target-specific monoclonal antibodies based on the binding. However, for complex membrane proteins, such as G protein-coupled receptors (GPCRs), binding-based screening rarely results in functional antibodies. Here we describe a...
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| Publicado no: | Commun Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7099005/ https://ncbi.nlm.nih.gov/pubmed/32218528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-0867-7 |
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