High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139

AIM: To discover antagonists of the orphan G-protein coupled receptor GPR139 through high-throughput screening of a collection of diverse small molecules. METHODS: Calcium mobilization assays were used to identify initial hits and for subsequent confirmation studies. RESULTS: Five small molecule ant...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Wang, Jia, Zhu, Lin-yun, Liu, Qing, Hentzer, Morten, Smith, Garrick Paul, Wang, Ming-wei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648122/
https://ncbi.nlm.nih.gov/pubmed/26027661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.12
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