Discovery and SAR of a Series of Agonists at Orphan G Protein-Coupled Receptor 139

[Image: see text] GPR139 is an orphan G-protein coupled receptor (GPCR) which is primarily expressed in the central nervous system (CNS). In order to explore the biological function of this receptor, selective tool compounds are required. A screening campaign identified compound 1a as a high potency...

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Detalhes bibliográficos
Main Authors: Shi, Feng, Shen, Jing Kang, Chen, Danqi, Fog, Karina, Thirstrup, Kenneth, Hentzer, Morten, Karlsson, Jens-Jakob, Menon, Veena, Jones, Kenneth A., Smith, Kelli E., Smith, Garrick
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028000/
https://ncbi.nlm.nih.gov/pubmed/24900311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100293q
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