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Protection of Primary Dopaminergic Midbrain Neurons by GPR139 Agonists Supports Different Mechanisms of MPP(+) and Rotenone Toxicity

The G-protein coupled receptor 139 (GPR139) is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. Here, we examined the potential neuroprotective effect of GP...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Bayer Andersen, Kirsten, Leander Johansen, Jens, Hentzer, Morten, Smith, Garrick Paul, Dietz, Gunnar P. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923153/
https://ncbi.nlm.nih.gov/pubmed/27445691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00164
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