The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site

GPR139 is an orphan G protein-coupled receptor expressed in the brain, in particular in the habenula, hypothalamus and striatum. It has therefore been suggested that GPR139 is a possible target for metabolic disorders and Parkinson’s disease. Several surrogate agonist series have been published for...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nøhr, Anne Cathrine, Jespers, Willem, Shehata, Mohamed A., Floryan, Leonard, Isberg, Vignir, Andersen, Kirsten Bayer, Åqvist, Johan, Gutiérrez-de-Terán, Hugo, Bräuner-Osborne, Hans, Gloriam, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430874/
https://ncbi.nlm.nih.gov/pubmed/28442765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01049-z
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