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Discovery of Tricyclic Xanthines as Agonists of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18

[Image: see text] GPR18 is a rhodopsin-like orphan G-protein-coupled receptor (GPCR) that is activated by the natural cannabinoid (CB) Δ(9)-tetrahydrocannabinol (THC). It is highly expressed in immune cells and represents a promising new drug target. However, THC is much more potent in activating CB...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Schoeder, Clara T., Mahardhika, Andhika B., Drabczyńska, Anna, Kieć-Kononowicz, Katarzyna, Müller, Christa E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549263/
https://ncbi.nlm.nih.gov/pubmed/33062188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00208
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