Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties

A library of 27 novel amide derivatives of annelated xanthines was designed and synthesized. The new compounds represent 1,3-dipropyl- and 1,3-dibutyl-pyrimido[2,1-f]purinedione-9-ethylphenoxy derivatives including a CH(2)CONH linker between the (CH(2))(2)-amino group and the phenoxy moiety. A synth...

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Publicado no:Medchemcomm
Principais autores: Załuski, Michał, Stanuch, Katarzyna, Karcz, Tadeusz, Hinz, Sonja, Latacz, Gniewomir, Szymańska, Ewa, Schabikowski, Jakub, Doroż-Płonka, Agata, Handzlik, Jadwiga, Drabczyńska, Anna, Müller, Christa E., Kieć-Kononowicz, Katarzyna
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071793/
https://ncbi.nlm.nih.gov/pubmed/30108984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00070k
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