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Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties
A library of 27 novel amide derivatives of annelated xanthines was designed and synthesized. The new compounds represent 1,3-dipropyl- and 1,3-dibutyl-pyrimido[2,1-f]purinedione-9-ethylphenoxy derivatives including a CH(2)CONH linker between the (CH(2))(2)-amino group and the phenoxy moiety. A synth...
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| Published in: | Medchemcomm |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Royal Society of Chemistry
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6071793/ https://ncbi.nlm.nih.gov/pubmed/30108984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00070k |
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