Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18

GPR18 is an orphan G protein-coupled receptor (GPCR) expressed in cells of the immune system. It is activated by the cannabinoid receptor (CB) agonist ∆(9)-tetrahydrocannabinol (THC). Several further lipids have been proposed to act as GPR18 agonists, but these results still require unambiguous conf...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Neumann, Alexander, Engel, Viktor, Mahardhika, Andhika B., Schoeder, Clara T., Namasivayam, Vigneshwaran, Kieć-Kononowicz, Katarzyna, Müller, Christa E.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7277601/
https://ncbi.nlm.nih.gov/pubmed/32365486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10050686
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