The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity

Interleukin-3 (IL-3) receptor α (IL-3Rα) is the α subunit of the ligand-specific IL-3R and initiates intracellular signaling in response to IL-3. IL-3 amplifies proinflammatory signaling and cytokine storm in murine sepsis models. Here we found that RNFT2 (RING finger transmembrane-domain containing...

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Publicado en:JCI Insight
Autores principales: Tong, Yao, Lear, Travis B., Evankovich, John, Chen, Yanwen, Londino, James D., Myerburg, Michael M., Zhang, Yingze, Popescu, Iulia D., McDyer, John F., McVerry, Bryan J., Lockwood, Karina C., Jurczak, Michael J., Liu, Yuan, Chen, Bill B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098800/
https://ncbi.nlm.nih.gov/pubmed/31990690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133652
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