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RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity
Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through the ubiquitination and degradation of the recept...
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| I publikationen: | eLife |
|---|---|
| Huvudupphovsmän: | , , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
eLife Sciences Publications, Ltd
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5092053/ https://ncbi.nlm.nih.gov/pubmed/27805901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18496 |
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