RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity

Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types of PAMPs that originate from gram-positive bacteria. Here we describe a novel mechanism regulating TLR2 protein expression and subsequent cytokine release through the ubiquitination and degradation of the recept...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: McKelvey, Alison C, Lear, Travis B, Dunn, Sarah R, Evankovich, John, Londino, James D, Bednash, Joseph S, Zhang, Yingze, McVerry, Bryan J, Liu, Yuan, Chen, Bill B
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2016
Ämnen:
Biochemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5092053/
https://ncbi.nlm.nih.gov/pubmed/27805901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18496
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