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The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity
Interleukin-3 (IL-3) receptor α (IL-3Rα) is the α subunit of the ligand-specific IL-3R and initiates intracellular signaling in response to IL-3. IL-3 amplifies proinflammatory signaling and cytokine storm in murine sepsis models. Here we found that RNFT2 (RING finger transmembrane-domain containing...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7098800/ https://ncbi.nlm.nih.gov/pubmed/31990690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133652 |
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