A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry

SARS-CoV-2 (2019-nCoV) is the pathogenic coronavirus responsible for the global pandemic of COVID-19 disease. The Spike (S) protein of SARS-CoV-2 attaches to host lung epithelial cells through the cell surface receptor ACE2, a process dependent on host proteases including TMPRSS2. Here, we identifie...

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Publicado no:Res Sq
Main Authors: Chen, Yanwen, Lear, Travis B., Evankovich, John W., Larsen, Mads B., Lin, Bo, Alfaras, Irene, Kennerdell, Jason R., Salminen, Laura, Camarco, Daniel P., Lockwood, Karina C., Liu, Jie, Myerburg, Michael M., McDyer, John F., Liu, Yuan, Finkel, Toren, Chen, Bill B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Journal Experts 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430593/
https://ncbi.nlm.nih.gov/pubmed/32818215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21203/rs.3.rs-48659/v1
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