A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis

NRF2 is a master regulator of cellular anti-oxidant and anti-inflammatory responses, and strategies to augment NRF2-dependent responses may beneficial in many diseases. Basal NRF2 protein level is constrained by constitutive KEAP1-mediated degradation, but in the presence of electrophiles, NRF2 ubiq...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Chen, Yanwen, Evankovich, John W., Lear, Travis B., Tuncer, Ferhan, Kennerdell, Jason R., Camarco, Daniel P., Shishido, Morgan S., Liu, Yuan, Chen, Bill B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068124/
https://ncbi.nlm.nih.gov/pubmed/32171724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101485
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