Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis

Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with excessive profibrotic signaling, affecting skin, cardiovascular, and particularly lung tissue. Over three-quarters of individuals with SSc develop p...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Lear, Travis B., Lockwood, Karina C., Larsen, Mads, Tuncer, Ferhan, Kennerdell, Jason R., Morse, Christina, Valenzi, Eleanor, Tabib, Tracy, Jurczak, Michael J., Kass, Daniel J., Evankovich, John W., Finkel, Toren, Lafyatis, Robert, Liu, Yuan, Chen, Bill B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105301/
https://ncbi.nlm.nih.gov/pubmed/32071084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.012066
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