Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis

Systemic scleroderma (SSc) is an autoimmune disease that affects over 2.5 million people globally. SSc results in dysfunctional connective tissues with excessive profibrotic signaling, affecting skin, cardiovascular, and particularly lung tissue. Over three-quarters of individuals with SSc develop p...

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Vydáno v:J Biol Chem
Hlavní autoři: Lear, Travis B., Lockwood, Karina C., Larsen, Mads, Tuncer, Ferhan, Kennerdell, Jason R., Morse, Christina, Valenzi, Eleanor, Tabib, Tracy, Jurczak, Michael J., Kass, Daniel J., Evankovich, John W., Finkel, Toren, Lafyatis, Robert, Liu, Yuan, Chen, Bill B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105301/
https://ncbi.nlm.nih.gov/pubmed/32071084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC119.012066
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