A high throughput screen for TMPRSS2 expression identifies FDA‐approved and clinically advanced compounds that can limit SARS‐CoV‐2 entry

SARS‐CoV‐2 (2019‐nCoV) is the pathogenic coronavirus responsible for the global pandemic of COVID‐19 disease. The Spike (S) protein of SARS‐CoV‐2 attaches to host lung epithelial cells through the cell surface receptor ACE2, a process dependent on host proteases including TMPRSS2. Here, we identifie...

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Detaylı Bibliyografya
Yayımlandı:FASEB J
Asıl Yazarlar: Lear, Travis, Chen, Yanwen, Evankovich, John, Larsen, Mads, Lin, Bo, Alfaras, Irene, Kennerdell, Jason, Salminen, Laura, Camarco, Daniel, Lockwood, Karina, Tuncer, Ferhan, Liu, Jie, Myerburg, Michael, McDyer, John, Liu, Yuan, Finkel, Toren, Chen, Bill
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Federation of American Societies for Experimental Biology 2021
Konular:
Biochemistry and Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8239878/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fasebj.2021.35.S1.03915
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