MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity

The ciliopathies Bardet-Biedl syndrome and Alström syndrome are genetically inherited pleiotropic disorders with hyperphagia and obesity as primary clinical features. Methionine aminopeptidase 2 inhibitors (MetAP2i) have been shown in preclinical and clinical studies to reduce food intake, body weig...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Pottorf, Tana S., Fagan, Micaella P., Burkey, Bryan F., Cho, David J., Vath, James E., Tran, Pamela V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7098713/
https://ncbi.nlm.nih.gov/pubmed/31877115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.134278
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