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Structural basis for allosteric modulation of class B GPCRs

Recent advances in our understanding of the structure and function of class B GPCRs provide multiple opportunities for targeted development of allosteric modulators. Given the pleiotrophic signaling patterns emanating from these receptors in response to a variety of natural agonist ligands, modulato...

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Bibliografiske detaljer
Udgivet i:Annu Rev Pharmacol Toxicol
Main Authors: Wootten, Denise, Miller, Laurence J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092389/
https://ncbi.nlm.nih.gov/pubmed/31454292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010919-023301
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