Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits

Extensive studies with subtype A BG505-derived HIV envelope glycoprotein (Env) immunogens have revealed that the dominant autologous neutralizing epitope in rabbits is located in an exposed region of the heavily glycosylated trimer that lacks potential N-linked glycosylation sites at positions 230,...

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Udgivet i:J Virol
Main Authors: Yang, Yuhe R., McCoy, Laura E., van Gils, Marit J., Andrabi, Raiees, Turner, Hannah L., Yuan, Meng, Cottrell, Christopher A., Ozorowski, Gabriel, Voss, James, Pauthner, Matthias, Polveroni, Thomas M., Messmer, Terrence, Wilson, Ian A., Sanders, Rogier W., Burton, Dennis R., Ward, Andrew B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081899/
https://ncbi.nlm.nih.gov/pubmed/31941772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01861-19
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