Autologous Antibody Responses to an HIV Envelope Glycan Hole Are Not Easily Broadened in Rabbits

Extensive studies with subtype A BG505-derived HIV envelope glycoprotein (Env) immunogens have revealed that the dominant autologous neutralizing epitope in rabbits is located in an exposed region of the heavily glycosylated trimer that lacks potential N-linked glycosylation sites at positions 230,...

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Pubblicato in:J Virol
Autori principali: Yang, Yuhe R., McCoy, Laura E., van Gils, Marit J., Andrabi, Raiees, Turner, Hannah L., Yuan, Meng, Cottrell, Christopher A., Ozorowski, Gabriel, Voss, James, Pauthner, Matthias, Polveroni, Thomas M., Messmer, Terrence, Wilson, Ian A., Sanders, Rogier W., Burton, Dennis R., Ward, Andrew B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7081899/
https://ncbi.nlm.nih.gov/pubmed/31941772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01861-19
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