The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.

Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robust protection against autologous intra-vaginal simi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tysheena P Charles, Samantha L Burton, Prabhu S Arunachalam, Christopher A Cottrell, Leigh M Sewall, Venkata S Bollimpelli, Sailaja Gangadhara, Antu K Dey, Andrew B Ward, George M Shaw, Eric Hunter, Rama R Amara, Bali Pulendran, Marit J van Gils, Cynthia A Derdeyn
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science (PLoS) 2021-02-01
Cyfres:PLoS Pathogens
Mynediad Ar-lein:https://doi.org/10.1371/journal.ppat.1009257
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg