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Enantio- and Diastereoselective Synthesis of Homoallylic α‑Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes

We describe a strategy for the enantio- and diastereoselective synthesis of homoallylic α-trifluoromethyl amines by the catalytic hydroalkylation of terminal dienes. Trifluoromethyl-substituted isatin-derived azadienolate nucleophiles undergo γ-selective alkylation with a Pd–DTBM-SEGPHOS catalyst, w...

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Bibliografski detalji
Izdano u:Org Lett
Glavni autori: Onyeagusi, Chibueze I., Shao, Xinxin, Malcolmson, Steven J.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7079280/
https://ncbi.nlm.nih.gov/pubmed/32013445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c00342
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