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Diastereoselective synthesis of vicinal tertiary and N-substituted quaternary stereogenic centers by catalytic hydroalkylation of dienes

An efficient and diastereoselective (CDC)–Rh-catalyzed hydroalkylation of dienes with 1,3-oxazol-5(4H)-ones is reported. Aryl and alkyl substituted dienes are converted to α,α-substituted oxazolones (24 examples) by the formation of N-substituted quaternary carbon stereogenic centers in good yields...

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Bibliografski detalji
Izdano u:Chem Sci
Glavni autori: Goldfogel, Matthew J., Meek, Simon J.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6013916/
https://ncbi.nlm.nih.gov/pubmed/30155052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04908c
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